手性有機(jī)小分子催化劑因具有反應(yīng)條件溫和、環(huán)境友好、催化劑易于回收利用、符合綠色化學(xué)的要求等優(yōu)點(diǎn)，成為近年來(lái)不對(duì)稱催化領(lǐng)域發(fā)展起來(lái)的一個(gè)研究熱點(diǎn)。其中，手性環(huán)胍類有機(jī)小分子催化劑可用于不對(duì)稱的Michael加成反應(yīng)、Mannich反應(yīng)、脫羧反應(yīng)、胺化反應(yīng)及炔烴的手性連烯重排反應(yīng)等等，并可實(shí)現(xiàn)良好收率和立體選擇性，充分顯示了手性環(huán)胍小分子催化劑在不對(duì)稱反應(yīng)中的巨大潛力。

產(chǎn)品性質(zhì)穩(wěn)定，易于儲(chǔ)存；

反應(yīng)條件溫和，反應(yīng)易于操作；

反應(yīng)底物范圍廣，可催化多種反應(yīng)類型；

催化劑無(wú)金屬殘留，可用于制藥或香精香料生產(chǎn)；

高度優(yōu)勢(shì)的產(chǎn)品價(jià)格，齊全的包裝規(guī)格，國(guó)內(nèi)現(xiàn)貨量充足。

產(chǎn)品名稱

CAS

(2S,6S)-雙芐基五元二環(huán)胍

(2S,6S)-2,6-Di-benzyl-2,3,5,6-tetrahydro-1H-imidazo[1,2-a]imidazole

877773-30-3

(2S,6S)-雙叔丁基五元二環(huán)胍

(2S,6S)-2,6-Di-tert-butyl-2,3,5,6-tetrahydro-1H-imidazo[1,2-a]imidazole

877773-38-1

1. Biomimetic Enantioselective Decarboxylative Reactions catalysed by chiral bicyclic guanidine;

2. Bicyclic guanidine-catalyzed enantioselective Phospha-Michael reaction;

3. Bicyclic Guanidine-Catalyzed Direct Asymmetric Allylic Addition of N-Aryl Alkylidene-Succinimides;

4. Enantioselective Protonation Catalyzed by a Chiral Bicyclic Guanidine;

5. Chiral bicyclic guanidine catalysed Mannich reaction;

6. Enantiodivergent and g-Selective Asymmetric Allylic Amination;

7. Enantioselective Synthesis of Chiral Allenoates by Guanidine-Catalyzed Isomerization of 3-Alkynoates.

Ref.:

[1].Chem. Eur. J.2011, 17, 8363 - 8370;

[2].Chemical Commununications,2007, 47, 5058-5060;

[3].Chem. Eur. J.2010, 16, 12534 - 12537;

[4].Angew. Chem. Int. Ed.2008, 47, 5641 - 5645;

[5].a).Chem. Eur. J.2011, 17, 3571 - 3574;b).Chem. Eur. J.2010, 16, 779 -782;

[6].Angew. Chem. Int. Ed.2012, 51, 1 - 6;

[7].J. Am. Chem. Soc.2009, 131, 7212 - 7213.

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